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  A revolutionary cancer-targeting technology developed by researchers at Immunocore Limited has been described for the first time in the prestigious medical journal, Nature Medicine.The new reagents known as ImmTACs (Immune Mobilizing mTCR against Cancer) mobilize T cells to kill cancer cells and overcome immune toleranc dunk nike low e to cancer.The most advanced of Immunocore鈥檚 ImmTACs, a drug called IMCgp100, dunk femme  is already in clinical trials in the UK and US for the treatment of melanoma.A second oncology ImmTAC, IMCmage1, is set to enter the clinic in both countries later this year and is applicable to the treatment of a large number of poorly served cancer indications.Antibody-based drugs have become a mainstay of cancer treatment, but their use is limited to the small fraction of cancer targets that present as whole proteins yeezy 700  on the cell surface. Most cancer targets are hidden inside cancerous cells where antibodies cannot reach them.By contrast, T cells employ T Cell Receptors (TCRs) which target t  LONDON:Steve McClaren was sacked as Newcastle United manager on Friday with the club facing relegation from the Prem adidas samba negras ier League 10 matches from the end of the season.McClaren's position has been under threat for weeks and speculation intensified after fans tur adidas adidas samba ned on him during the 3-1 home defeat by Bournemouth on Saturday."After the defeat to Bournemouth the Club has spent some time considering its position and today concluded that Steve McClaren's employment with the Club will end wit nb 530 h immediate effect," Newcastle said in a statement.Shelvey joins Newcastle from SwanseaMcClaren, 54, a former England manager, signed a three-year deal to become Newcastle boss in June and was also appointed to the club's board of directors.But Newcastle have never recovered from a poor start to the season in which they failed to win any of their opening eight league matches.They are 19th in the 20-team standings and facing a return to the second tier for the first time since 2010.Carroll caps Hammers fig