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Oncothyreon Inc. and Array BioPharma Inc. have announced the initiation of a Phase 1b trial of ONT-38
yeezys 0 (ARRY-380) in combination wi
yeezy slides th Kadcyla庐 (ado-trastuzumab emtansine or TDM-1) in patients with metastatic HER2+ breast cancer.ONT-380 is an orally active, reversible and selective small-molecule HER2 inhibitor invented by Array and being developed by Oncothyreon in collaboration with Array.The trial (ClinicalTrials.gov Identifier NCT01983501) is a dose-escalation study in up to 48 patients who have been previously treated with Herceptin庐 (trastuzumab)
dunk femme and a taxane for metastatic breast cancer.The primary objective is to determine the maximum-tolerated and/or recommended Phase 2 dose (MTD/RP2D) of ONT-380 in combination with the approved dose of Kadcyla.Secondary objectives include an evaluation of the safety and preliminary anti-tumor activity of the combination. Following determination of the MTD/RP2D, the study includes an expansion arm at the MTD/RP2D as well as an optional second e SYDNEY:The head of Australia's Anglican Church expressed sorrow and shame after a government report published
adidas samba adidas on Friday said close to 1,100 people had filed child sexual assault claims against the church over a 35-year period.The interim report, which said
nb 550 most children were aged around 11 when they were abused, came a month after a high-level in
adidas campus rose quiry into child abuse was told the Australian Catholic church had paid A$276 million ($212 million) in compensation to thousands of victims since 1980.Bishops could be fired over 'negligence' on child abuse: popeThe report, which was published by the same inquiry, the Royal Commission Into Child Abuse, said the complaints identified 569 Anglican clergy, teachers and volunteers as alleged abusers. There were another 133 alleged abusers whose roles at the church were not known.Melbourne Archbishop Philip Freier said he felt a "personal sense of shame and sorrow" at the way the church had apparently silenced victims."Anglicans have been truly sho
