Ogyv Master Gene that Switches on Disease-Fighting Cells Identified by Scientists
CRISPR-Cas3 is a subtype of the CRISPR-Cas system, a widely adopted mol
asics ecular tool for precision gene editing in biomedical research. Aspects of its mechanism of action, however, particularly how it searches for its DNA targets, were unclear, and concerns about unintended off-target effects have raised questions about the safety of CRISPR-Cas for treating human diseases.Harvard Medical School and Cornell University scientists have now generated near-atomic resolution snapshots of CRISPR that reveal key steps in its mechanism of action. The findings, published in Cell on June 29, provide the structural data necessary for efforts to improve the efficiency and accuracy of CRISPR for biomedical applications.Through cryo-electron microscopy, the r
adidas yeezys esearchers descr
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