Ehhv A shrewd move
Mayo Clinic researchers have identified a new cause of treatment resistance in prostate cancer. Their discovery also suggests ways to improve prostate cancer therapy. The findings appear in Nature Medicine.In the
air force 1 damen publication, the authors explain the role of mutations within the SPOP gene on the development of resistance to one class of drugs. SPOP mutations are the most frequent genetic changes seen in primary prostate cancer. These mutations play a central role in the development of resistance to drugs called BET-inhibitors.BET, bromodomain and extra-terminal domain, inhibitors are drugs that prevent the action of BET proteins. These proteins help guide the abnormal growth of cancer cells.As a therapy, BET-inhibitors are promising, but drug resistance often develops, says Haojie Huang, Ph.D., senior author and a molecular biologist
nbbalance within Mayo Clinic鈥檚 Center for Biomedical Discovery. Prostate cancer is among the most
asic schuh diagnosed malignancies in the United States. It is also the third l Archaeologists, historians, scholars and intellectuals stressed upon the need for the people of the province to extend their cooperation for the ownership, protection and preservation of cultural and archaeological heritage of Sindh, including Ranikot Fort, which is also known as the Great Wall of Sindh.They were speaking at the first
nb 574 ever 'Much Kachahry [camp fire gathering]', which was organised by
adidas campus uomo the culture department in collaboration with Banhbeli, Sindh Historical Heritage Society and Sindh Graduate Association.The event was held in Merikot, a fortress inside the main Ranikot
newbalance 990 Fort, Saturday night and attended by hundreds of people who braved the severe cold.Besides discussions on preserving heritage sites, people were also entertained by Sughars, the centuries old tradition in which people share their experiences through oral recitation of poetry.Dr Epich Rand, an American archaeologist, remarked that he was astonished to see the fort. The fort will attract tourists and archaeol
