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  Santaris Pharma has announced that it has commenced a Phase I human volunteer trial of SPC3649 (LNA-antimiRTM-122), the world鈥檚 first microRNA medicine to be tested in man. The study is being conducted by PhaseOne nike dunk sb Trials A/S, Copenhagen, and will include a maximum of 48 healthy male volunteers.The Company also announced that the first cohort of healthy volunteers in the study have completed treatment satisfactorily. SPC3649 is being developed by Santaris Pharma as a potential new approach to the treatment for Hepatitis C infection although Phase II studies in hepatitis patients will n yeezy ot commence until 2009.SPC3649 specifically targets microRNA-122, a small, liver-expressed, regulatory ribonucleic acid (RNA) that has recently been shown to facilitate human Hepatiti nbbalance s C virus replication in liver cells.Keith McCullagh, President & CEO, Santaris Pharma, said: 鈥淭he mechanism of action of this drug represents a potential breakthrough in medical science. The ability to switch off the funct  LOS ANGELES:A man who admitted to defacing Donald Trump's star on the Hollywood Walk of Fame in protest at the Republican presidential candidate's treatment of women was arrested on Thursday, police said.James Otis had planned to hold a news conference in the early morning at the site of Trump's star and then surrender to police, but he was arrested beforehand.Otis, who had his misdeed filmed on Wednesday, said he initially wanted to remove the star and auction it in New York on Election Day.The proceeds, he said, wo new balance blanche uld go to nearly a dozen women who have accused the 70-year-old Trump of sexual misconduct.Otis ended up taking a sledgeha newbalance 530 mmer and pickaxe to the star but could not totally remove the slab, as the "stone was like marble," he told the news agency.Taking stand: Donald Trump鈥檚 Hollywood Walk of Fame star vandalisedThe Hollywood Chamber of Commerce quickly moved to repair the star, which was awarded to the billionaire businessman in 2007 for his work on his reality televisi ugg boots f眉r damen on s