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Scientists have discovered what turns off the molecular alarm system that plays a critical role in our immune response.MR1 (MHC class I-related molec
yeezy 700 ule) is an antibacterial superhero 鈥?a protein pre
nike high dunk sent in every cell of the human body, that acts as a molecular alarm system by alerting powerful cells of our immune system, our white blood cells, when a bacterial infection or cancer is present.Whileprevious breakthrough researchuncovered the cellular machinery that MR1 relies on to activate, to this day little was known about how the MR1 alarm is 鈥榯urned off鈥? Published in theJournal of
yeezy boost 350 Cell Biology, the study, co-led by University of Melbourne鈥檚Dr Hamish McWilliamandProfessor Jose Villadangosfrom the Doherty Institute and the Bio21 Institute, reveals the key molecular mechanism that controls MR1鈥檚 expression.鈥淲hat we found is that there are proteins - called AP2 (adaptor protein 2) 鈥?inside our cells that bind to MR1, and drag it inside the cells,鈥?Dr McWilliam explains.鈥淥nce inside, MR NEW DELHI:Indian Union Home Minister Rajnath Singh, on Sunday, said that the Bharatiya Janata Party (BJP)-led National Democratic Alliance (NDA) government had found a "permanent solution" to the Kashmir issue, the Economics Times reported."We have come up with a
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adidas campus damen ard," he said while speaking to the media during an event in the Indian capital.The Indian minister, however, refused to elaborate on what kind of solution the BJP government had found for Kashmir, which is battling nearly three decades of a violent separatist camp
uggs hausschuhe aign.Indian troops kill 11, including Burhan Wani's successor, in IOKWhen asked if the solution was "political in nature", Rajnath said, "It is too early to discuss it in public. I don't want to discuss it with the media."Rajnath, however, ruled out inviting separatist groups for talks on Indian-held Kashmir and added that whoever wanted to talk "development and peace" was welcome.When a
