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  Cancer Research UK scientist yeezy slide s at the University of Southampton found that this molecule targets the master switch 鈥?HIF-1 鈥?that cancer cells use to adapt to low oxygen levels, a common feature in the disease.The researchers uncovered a way to stop cancer cells using this switch through an approach called 鈥榮ynthetic biology鈥? By testing 3.2 million potential compounds, made by specially engineered bacteria, they were ab yeezy boost le to find a molecule that stopped HIF-1 from working.All cells need a blood supply to provide them with the oxygen and nutrients they require to survive. Cancer tumours grow rapidly a nike dunk sb nd as the tumour gets bigger it outstrips the supply of oxygen and nutrients that the surrounding blood vessels can deliver.But, to cope with this low-oxygen environment, HIF-1 acts as a master switch that turns on hundreds of genes, allowing cancer cells to survive. HIF-1 triggers the formation of new blood vessels around tumours, causing more oxygen and nutrients to be delivered to the st  ISLAMABAD:A team from the France-based ATR aircraft manufacturer may join Pakistani  adidas samba investigators in probing the cause of the Pakistan International Airlines (PIA) plane crash that killed all 4 adidas campus uomo 7 people on board on December 7.鈥淭he officials of the ATR have contacted PIA for assistance in the probe,鈥?said the PIA spokesperson Danyal Gilani on Saturday. In response to a question, he confirmed that soon after the tragic incident, the ATR company had contacted PIA, offering its help in the probe.Ho new balance donna wever, as the Safety and Investigation Board (SIB) is investigating the matter independently, the PIA referred the ATR to the SIB, which will decide when and whether to engage them. 鈥淭he final decision in this regard will be taken by the SIB,鈥?he said.PIA鈥檚 flight PK-661 en route to Islamabad from the northern city of Chitral had crashed into a hillside near Abbottabad after one of its two turboprop engines failed and burst into flames.Among those on board was Junaid Jamshed, a former singer-turne