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 Resistance to malaria drugs in Africa may be starting to take hold, according to a study that maps changes similar to those seen a decade ago when drug resistance spread in south-east Asia.In Cambodia and neighbouring countries, the artemisinin drug compounds widely used against malaria are no longer always effective. The falciparum malaria parasites have developed genetic mutations that allow them to evade the drugs. There has been great concern that drug resistance could spread to Africa, which has the highest burden of cases of this type of malaria 鈥?and the highest toll of child deaths from it.A study in Rwanda, published in stanley botella  the Lancet Infectious Diseases journal on Wednesday, shows that the feared erosion of efficacy of the malaria drugs may have begun. As happened in south-east Asia, researchers have found that giving a child a course of artemisinin compound drugs does not always clear the malaria parasites from their blood in three days, as it should.Artemisinins, introduced in the early 2000s from China, are given in combination with a different type of malaria drug to ensure all parasites are cleared and the efficacy of the drugs is not compromised. The most common combination is artemether- stanley cup lumefantrine, which Rwanda began to use in 2006.If the artemisinin drug does not clear the parasites promptly within three days, the  starbucks stanley cup partner drug comes under pressure and resistance to it may develop in turn. At that point, the treatment may fail, as has happened in south-east Asi Trkk Letters: Ofsted, take note 鈥?learning is about more than recall
 Lord Justice Leveson delivered his 2,000-page report this week on the  culture, practice and ethics of the press . His headline conclusion was that the current regulator, the Press Complaints Commission, has proved inadequate and should be replaced with a fully independent body, backed if need be by new law.David Cameron, who commissioned the report following the phone-hacking scandal, initially rejected that final clause regarding new legislation. In a highly unusual move, the deputy prime minister Nick Clegg gave his own address to parliament in which he accepted Leveson s broad proposals.Joining John Plunkett in the studio for this joint edition of our Politics Weekly and Media Talk podcasts to discuss what happens now are media editor Dan Sabbagh; former Daily Mirror editor Roy Greenslade; political columnist Michael White; and former PCC chair Stig Abell.We also hear from the Guardian s editor Alan Rusbridger, Observer columnist Nick Cohen and Hacked Off spokesman Evan Harris.Leveson composi stanley cup te. Photograph: guardian.co.uk Photograph: guardian.co.ukExplore more on these topics stanley cup quencher Leveson inquiryMediaGuardianBrian Leves stanley cup onDavid CameronNick CleggConservativesNewspapers  magazinesHacked Off campaignMost viewedMost viewedUKUK politicsEducationMediaSocietyLawScotlandWalesNorthern Ireland