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While it not the first rewritable biological storage system to be made鈥攐thers have used proteins which bond to DNA to perform a similar function鈥攊t is the first time such an effect has been achieved in the DNA itself, and it could make sy
stanley kubek nthetic digital cells a possibility. To achieve it the researchers, from Stanford University, spliced genetic elements from a bacterium-infecting virus into the
stanley mexico DNA of Escherichia coli. What they were left with is a system which contains a stretch of DNA flanked by sites which indicate to enzymes that the DNA can be cut and then pasted in reverse orientation鈥攁nd that just what happens.
stanley france In fact, the process can be performed over and over, with the team so far demonstrating that is can be done at least 16 times. In fact, the project, which is pubslished in PNAS, took three years and 750 designs to work properly. Drew Endy, the lead researcher behind the prohect, explains to Nature: It a pretty sad criticism of the state of technology in synthetic biology where we ;re trying to program the expression of half a dozen genes and it takes 750 design attempts to get that working. It like trying to write a six-line code on a computer that takes 750 debug attempts to work. But even though it took so long to get, right, it a big achievement. Eric Klavins, of the University of Washington in Seattle, explains to Nature why the finding is so interesting: What Drew