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In a study led by Yale neurobiologist Tamas Horvath, researchers injected cannabinoids into the brains of lab mice, activating a cannabinoid recepto
stanley cup website r called CB1R. Previous studies have shown that activation of CB1R increases the desire to eat, and Horvath investigation confirmed this. We show that chemical promotion of CB1R activity increases feeding, the researchers write in this week issue of Nature. Makes sense. This is what they were expecting. So far, so stoned. But then the researchers noticed
stanley quencher something they hadn ;t expected. CB1R activity, in addition to promoting hunger, had also boosted activity in a group of nerve cells called hypothalamic pro-opiomelanocortin POMC neurons, a tongue-twisting class of brain cells that, under normal circumstances, works to suppress appetite. The observation posed a mechanistic paradox: why were POMC neurons being activated in the brains of hungry mice It not like CB1R hunger-boosting activity was somehow overpowering the hunger-suppressing properties of POMC neurons, either. When Horvath and his colleagues artificially suppressed POMC neuron activity, it diminished CB1R-driven feeding. When they increased POMC neuron activity, feeding was enhanced. The paradoxical increase in POMC activity, write the researchers, is indispensable for appropriate p
stanley cup romotion of feeding triggered by CB1R activity in the state of satiety. In other words, POMC activity was cr Mlkk Microsoft Admit to Hacks Based on Findings in Googler s Report
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