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  When a protein named "Merlin" fails to do its job, people can develop slow-growing, life-disrupting auditory nerve tumors that can disrupt their hearing and balance. This rare condition is called neurofibromatosis 2 (NF2).Now scientists at Cincinnati Children's have discovered mu air jordan4 ch more about how Merlin does its job--by working behind the scenes through a network of more than 50 other proteins. For people afflicted by NF2, this discovery advances the hunt for drug therapies for a condition that, so far, has required surgery to treat.But the findings also advance a concept with far wider implications for cancer research--that tumors have impaired response to physical forces and other mechanical signals. This opens up ne tenis yeezys w possibilites to develop novel cancer therapies.These findings, led by first author Robert Hennigan, PhD, and senior author Nancy Ratner, PhD, were published onl dunk nike low ine April 23, 2019, in Science Signaling. The paper reflects the culmination of more than seven years of resea  ISLAMABAD:The draft stanley-cup  of National Food Security Policy had been finalised in order to achieve zero hunger targets in the country, Minister for National Food Security  adidas campus 80s and Research Sikandar Hayat Bosan said here Friday.Addressing an event zapatillas nb  organised to commemorate the World Food Day, he said that the document was presented to lawmakers and members of civil society for their input to make it a vibrant document to ensure food safety and security in the country.The event was organised by the Pakistan Agriculture Research Council (PARC) to highlight the significance of the day and to create awareness about climate change and its effects on the agriculture sector of the country.The theme of the day for this year was 鈥淐limate is changing, food and agriculture must too.鈥?The minister said that the food security policy document gave ample focus to crop diversification, climate change, natural disasters and zero hunger programme. He said there was immense pressure on natural resources and environmen

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Bwum Du Plessis return gives South Africa hope
  BioFocus DPI has announ dunk nike store ced two major enhancements to its ADMEnsa high-quality ADME optimizatio af1 shoes n services.In addition to opening a US-West Coast unit to better serve its customers, it has also upgraded the proprietary ADMEnsa Interactive software through improved data analysis and visualization. These capabilities enable the efficient design, identification and prioritization of compounds at all stages of the drug discovery process by indicating the optimal balance of properties critical to a compound鈥檚 success.Located in San Diego, the new ADMEnsa group builds on BioFocus DPI鈥檚 track record of success in drug discovery by providing flexible ADME optimization services. Taking a consultative approach, they aim to extract the greatest value from all ADME and DMPK data and advice on the next steps to move projects forward.The West Coast ADMEnsa team will be headed by Dr. Shamsi Raeissi, who brings with her extensive drug discovery and preclinical development knowledge gained  jordan through over 1  ISLAMABAD:In contradiction to the claim of two senior ministers in the National Assembly, the federal government has granted permission to multinational companies for commercialisation of genetically modified (GM) corn seeds in Pakistan.In this regard, the Ministry of Climate Change has awarded licences to different companies including Monsanto and DuPont/Pioneer.Sources in the ministry said t adidas sambarose he government gave the go-ahead without conducting a large-scale open field trial of the technology, which is a violation of new balance bleu  the national bio-safety laws and the international standard operating procedures.However, in response to a point of order raised by Pakistan Tehreek-e-Insaf MNA Dr Arif Alvi in the National Assembly last week, two federal ministers Khurram Dastgir a adidas sambarose nd Sikandar Hayat Khan Bosan categorically denied that the government had given licence to any multinational company for commercial trial of GM corn seeds in the country.Sources in the climate change ministry and experts claim tha

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Homy 600 containers of Pakistani rice stuck at Kenyan ports
 KARACHI:Virtuoso musicians in Pakistan, who have a tendency to travel into uncharted territory often end up spending the entirety  stanley brand of their career in a constant tug of war between ambition and artistic pursuits. The trajectory of such artists, identified聽by聽genres very much alien to the masses,聽can usually take two possible directions.They either fall prey to their own warped sense of  authenticity 聽and resort to playi air max95 ng music only for audience they deem  airmaxplus worthy i.e themselves. This naturally distances them from the public sphere and leaves behind聽a body of work just enough to聽echo their mythical persona.Or they are forever cursed to find the  perfect balance  between their art and business, which never existed in the first place and as a result morph into an underwhelming version of their own selves.In both cases, it is the cult-like fandom that suffers the most at the hands of their gods. It is a tragedy indeed that the hardcore fans that should be the source of an artist s vigour are  Ifoa King Charles risks being labeled  petty  after Prince Harry s latest snub
 ISLAMABAD:City managers on Friday took a step towards reviving a decade-old plan to install  yeezy slide a chairlift in the Margalla Hills when they decided to engage an international consultant to evaluate the project.The Capital Development Authority (CDA) will solicit expressions of interest from international consultancies to carry out technical and financial studies for th dunk homme e proposed chairlift.The CDA has identified two sites for the installation of chairlifts, one from Marghazar Zoo 鈥?at the foothills of the Margallas to Makhiala Peak near Pir Sohawa village, with a brief stopover at Daman-e-Koh 鈥?while the second one would start from Lakeview Park.The total length of the chairlift would be approximately 2.5 kilometres if the starting point is the zoo, said a concerned official.He said the final decision about the starting and culmination points would be decided after the project s technical study is comp stanley cups leted.  According to a rough estimate, the project will cost Rs1.5 billion,  the official

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Xzla IG Islamabad  SSP Operations to be replaced Interior Minister
 LAHORE: Only four per cent of children with special needs have access to schools in Pakistan,  University of Management and Technology (UMT) Department of Education Chairman Sajid Masood said on Thursday.He was talking at a panel discussion titled Inclusive Education: Access to Quality nike air max97  Education of Children with Special Needs and Role of Teachers arranged by Alif Ailaan in collaboration with the UMT.Masood said 66 per cent of disabled people in Pakistan lived in rural areas, and 34 per cent in urban areas.He said 58 per cent of people with disabilities were male.Masood said the statistics of children with disabilities were approxima tenis yeezys te as there had been no national census since 1998.He said school campuses should be designed to provide for with disabilities.Dean Abdul Hamid said in 2010, the Special Education Department had star dunk ted a door-to-door campaign to search for people with disabilities He said in Shiekhupura 2,000 with people disabilities were registered. He said the actual figu HYDERABAD:The former chief minister Syed Murad Ali Shah has expressed wish to see Muttahida Qaumi Mo newbalance 550 vement-Pakistan contesting the upcoming general elections because he believed that the party is fearful of the voters.  quot;We had tried a lot to nike air max97  convince MQM-P to take part in the  air max90 local government elections but they boycotted the polls, quot; he recalled while talking to the media in Aarazi area of Sehwan, Jamshoro district, on Thursday.

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Xnja English Premier League Moyes displeased with  scandalous  decision
 CAIRO:Egypt s authorities on Friday formally detained Mohamed Morsi on suspicion of collaborating with Palestinian militants in murdering policemen and staging prison breaks, as tens of thousands of the deposed president s supporters and opponents staged rival rallies.Morsi s detention, under a court order, for a renewable 15 days further ramped up tension as those applauding the decision and those angrily demanding their leader s reinstatement flooded various parts of Cairo.The Arab world s most populous country has been convulsed by  yeezy 700 violence dunk low  for the past three weeks, with some 200 people killed since Morsi s ouster by the army on July 3, many in clashes between his supporters and his opponents.Clashes broke out in Cairo s Shubra neighbourhood in the early afternoon, leaving 10 people wounded as the two sides trad dunk femme ed stones.Another 15 people were wounded in clashes in the Mediterranean city of Alexandria, the health ministry said. Police broke up the clashes with tear gas, state media  LIVERPOOL:Ajax Amsterdam coach Erik ten Hag insisted on Monday his side were much better than the team that lost to Liverpool in the Champions League in October and would prove more competitive when they meet again at Anfield on Tuesday.A draw would be enough for Liverpool to advance  converse plateau to the next phase of the Champions League while Ajax are still in contention for a top two place in Group D, sitting two points behind their hosts in the standings and level with Atalanta. quot;We are better attuned to each other, the form for a number of players has got a lot better and the team as a whole is performing much better as a result, quot; Ten Hag told a news conference.An own goal handed Liverpool a 1-0 win at the Amsterdam Arena in the opening group match for both on Oct. 21 and Ten Hag said they had learnt some lessons from that night. quot;If we had been a little more courageous then, more would have been possible.  nike air max97 We cr nike air max270 eated opportunities but did not finish them. quot;And we could have cre

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 FAISALABAD:At least 25,000 armed police personnel are required to maintain law and order in the city, said Faisalabad City Police Officer (CPO) Riffat Mukhtar Raja on Saturday. Talking to media, the CPO said the district had a population of 7 million people but only 7,926 policemen. Strong liaison is required between police and the public to control street crime, he said.The shor yeezy 350 tage of security personnel has led to a surge in street crime. The indifference of some policemen towards the public can further aggravate the situation, said Raja. Faisalabad yeezys 700  had one policeman for every 1,000 citizens.  I have directed all station nike air max97  house officers to address citizens  complaints and ensure regular patrolling in their areas,  the CPO said.Published in The Express Tribune, May 26th, 2013. KOCHI:A former member of the Jehovah  39;s Witne nike air max97 sses group was detained for questioning about his alleged involvement in setting off homemade bombs at a meeting of the group in the southern Indian state of Kerala on Sunday, killing two women and injuring dozens of other people, police said.A 53-year-old woman succumbed to burn injuries, the health minister Veena George said stanley cup , bringing fatalities to two. A 12-year old girl with 95% burns remained in critical condition, George said.Dominic Martin posted a video on Facebook claiming responsibility for the attacks, before surrendering shortly after noon at a police station in Thrissur district, about 40 kilometers away from site of the explosions. quot;Dominic is still being questioned in Kochi nike air max . He is in our custody but we have not recorded his arrest so far, quot; police public relations officer Pramod Kumar told Reuters. quot;We are still trying to ascertain the veracity of his statement, it will take some time. We are not in a position t

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 At long last, there appears to be some ray of hope for sanity to prevail. The Supreme Court appears on the verge of breaking the bureaucratic logjam that has hitherto been preventing the advent of the third generation (3G) of mobile communication technology from  adidas yeezy being launched in Pakistan. If the honourable Court is able to finally force the government to stop the inordinate delays and hold a free and fair auction of 3G spectrum, then the nation will be in its debt. The government should be doing its best to accommodate the telecommunication industry. The five telecom operators between them have accounted for over one-third  stanleycup of all foreign direct investment over the past decade. They account for one in every Rs20 paid in taxes and employ tens of thousands of people. Fair market competition betw dunk nike store een them has meant that Pakistanis ensure some of the cheapest telecommunications costs in the world.With the 3G auction, the industry has had a fairly simple demand: if the government sets a reas RAWALPINDI:The cantonment boards of Rawalpindi and Chaklala have decided to end the practice of board employees working at homes of retired officers of the board.Many lower grade employees were working as drivers, gardeners, sanitary workers, security guards, watchmen and even computer operators for retired bosses of the cantonments. However, they were drawing salaries from the cantonment board.Both the cantonments in Rawalpindi have ordered their employees, who had been performing undesignated duties, to report back to the respective boards until May 4.The measure has been taken to discourage the deployment of cantonment bo new balance donna ard e nike 95 mployees on undesignated jobs a practice which has been going on for years.The boards  authorities learnt that there are dozens of employees who had been working at the houses of the retired cantonment high-ups and owing to their influence, no board has ever tried to summon the workers back to the duties they ha nike airmax 270 damen d been recruited for. However, ML amp;C director g

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Yycj K-P to set up dedicated body for CPEC-related projects
 ISLAMABAD:Jamiat Ulema-e-Islam-Fazl (JUI-F) chief Maulana Fazlur Rehman on Tuesday said talks with Tehreek-e-Taliban Pakistan (TTP) 鈥?stalled by US drone strike 鈥?were a must for peace. There are hurdles in the way of formulating an effective strategy includi stanley cup ng a forum for this purpose but talks with the Taliban are a must for peace,  Fazl said w dunk high hile addressing the media at National Press Club.Responding to a question, Fazl said it would be very unfortunate if an operation was launched against militants in March.The JUI-F chief said the issue had transformed into  a very sensitive  matter and that efforts were underway for peace which, accord adidas samba adidas ing to him, had been his party s stance since day one.Referring to the parliamentary resolutions during the previous government, he said the parliament had failed to implement them. But now we urge the incumbent government to formulate and implement an effective policy to tackle the issue,  he said, adding that there still was a need for all stakeh ISLAMABAD:Minister for Information and Broadcasting Attaullah Tarar on Monday assumed charge of the National Heritage and Culture Division.Prime Minister Shehbaz Sharif assig converse chucks ned the additional portfolio of National Heritage and Culture to Attaullah Tarar the other day.The Federal Secretary for National Heritage and Culture and other senior officials welcomed the minister on his arrival at the National Heritage and Culture Division.Federal Secretary for Information and Broadcasting Shaheera Shahid and Principal Information Officer Mubashir Hassan were also present on the occasion.Read Reconstituted missing persons committee to have parliamentary presenceThe National Heritage  nb 550 and Culture secretary gave a detailed briefing to the minister about the functioning of the Heritage and Culture Division.On t new balance uomo he occasion, the minister said,  ldquo;I am proud to have an opportunity to serve Pakistan at the national and international levels. rdquo;Responsibility of the National Heritage and Culture

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  ISLAMABAD:Senior PML-N leader Ishaq Dar, who has been nominated as the finance minister by the p adidas originals hamburg arty, on Tuesday was sworn in as a senator amid the hue an adidas campus 80s d cry raised by the opposition.Dar, who returned to Pakistan earlier in the day after spending almost five years in the UK on a   lsquo medical leave  rsquo , was administered oath of his office by Senate Chairman Sadiq Sanjrani.The PML-N leader had left the country in 2017 while standing trial in a corruption reference.As he entered the Senate hall, PML-N leaders welcomed him by thumping their desks.However, while he was being administered his oath of office, PTI senators shouted slogans including   ldquo absconder  rdquo  and surrounded the chairman  rsquo s rostrum.Some of them were even carrying placards and posters.The Senate chairman repeatedly asked them to return to their seats.He was compe air force homme lled to call in security to handle the situation.Speaking on the occasion, Law Minister Azam Nazeer Tarar said the PML-N welcomed Dar as a senat Yezp Two confectionery shop workers killed
 KARACHI:The most effective way to tackle a social issue at times is by looking at it in the most naive manner. While any grave air jordan3  issue warrants an in-depth look especially if it pertains to social injustices,聽as far as awareness is concerned, things should be put in a context that is both palatable and hits an emotional nerve.Take for instance Marjane Satrapi's animated feature Persepolis. The film manages聽to offer a first-hand experience of the drastic change in Iran's social fabric post the 1979 revolution by focusing on a young girl coming of age rather than dwelling on the facts and figures like a documentary.Similarly, Pakistan's first聽Netflix original Sitara- Let girls dream聽sheds light on the issue of child ma air max plus 3 rriages through the fun-loving and innocent eyes of a young girl.Written and directed by oscar-winning film-maker Sharmeen Obaid Chinoy, it's a fifteen- jordane one minute short that follows a 14-year-old girl named Pari in Lahore who aspires to become a pilot but is ultimately forced int

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Sped Two  child molesters  apprehended in Rawalpindi
  LAHORE:The Forest, Wildlife and Fisheries department has decided to plant nine million new saplings across the province during the monsoon season.The monsoon plantation campaign will continue in several districts and the department aims to prepare a total of 15 million plants in nurseries.A Plant for Pakistan cam adidas original samba paign day will be observed on August 1 when 224,200 saplings will be plant nike air max 95 ed across the province.Forest, Wildlife and Fisheries Department Deputy Director Mohammad Salim Malik said that th air force 1 e plantation campaign has kicked off during the monsoon season. This time, the target is to plant nine million new saplings. Green initiative: Govt to offer over 5,000 sites for tree plantation in SindhHe added that the success ratio of the Bahria plantation campaign was 128% after 150 million trees were planted instead of 120 million.He maintained that there are around 240 nurseries in different districts, including the provincial capital, where 15 million plants have been prepared.He said th Tqkv FTSE Russell retains Pakistan in secondary emerging markets
 LAHORE:Former Punjab chief minister Chaudhry Pervaiz Elahi has termed the incumbent government a   ldquo mafia  rdquo , saying that the rulin adidas spezial azul g Pakistan Democratic Movement is afraid of elections as every by-poll  rsquo s result is showing them their political status.  ldquo The country  rsquo s political and economic situation is demanding immediate general election, but the entire PDM is afraid o dunk high f elections,  rdquo  Elahi said during a meeting with a delegation of adidas originals superstar  the US House of Representatives, which called on him here.The 12-member was headed by US Democrat leader Dr Asif Mehmood and included California Legislative Assembly  rsquo s Appropriations Committee head Chris R Holden, his wife Melanie Caldwell Holden, Dloise Gomes, Mike A Gipson, Wendy Carrillo, Christopher Reyes, Anna Goddard, Willie Armstrong, Michael Meeks, Adriel Yang and others.Elahi told the delegation that the incompetent rulers  rsquo  gang had only one desire that somehow election should not be held.   ldquo The rulers wh

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Eumf Communication error SHO expresses ignorance over traffic cop killers  arrests
  NABLUS, PALESTINIAN TERRITORIES:Israel's military on Wednesday destroyed the West Bank home of a Palestinian accused of having killed two Israelis in March, the army said.Soldiers surrounded the home late on Tuesday in Az-Zawiya in the Salfit region of the occupied West Bank before carrying out the demolition using explosives and heavy machinery.Israel raid wounds three in centra nike airforce l Syria: state mediaOmar Amin Abu Laila was accused of fatally stabbing soldier Gal Keidan, 19, and stealing his weapon on March 17, the army said at the time.He then fired at Israeli motorists, hitting 47-year-old rabbi Ahiad Ettinger, a resident of the Eli settlement, who later died of his wounds, according to the a nike jordan femme  air max97 rmy.Abu Laila, 19, was shot dead two days later during an arrest raid by Israeli forces in the West Bank village of Abwein, north of Ramallah.Palestinian killed by Israel fire ahead of border protests: Gaza ministryIsraeli authorities accused Abu Laila of opening fire at forces, who killed him.Isra Aucx Car driven by  drunk cop  runs over motorcyclist
 RAWALPINDI:Female contractual anti-dengue sanitary employees staged a protest outside the office of the District Health Authority (DHA) against the strict conditions introduced for their regularisation.The protesters demanded that their ho nike air force one donna lidays, which have been suspended by the authority for the next thre nike air max97 e months as it embarks on an intensive anti-dengue campaign in the district, are restored, including the weekly holidays on Sunday.The DHA, in a letter recently issued to the 1,250 sanitary patrol workers, had directed them to ensure they report for duties over the next three months, including on the gazetted weekly holiday, Sunday.The workers were further instructed to come along with their appointment letters, service, and nation adidas samba shoes al identity cards along with an attested certificate from the related deputy district health officer (DDHO) to confirm their 100% attendance.Speakers stress need to protect sanitary workers  rsquo  rightsDHA warned workers of punitive action, including dismis

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Kaip Tributes laud Annan as man of peace and champion of rights
  KARACHI:The Karachi traffic police revealed an almost identical traffic plan for the T-20 match series between Pakistan and the West Indies as it devised for the recently concluded Pakistan Super League final. The T-20 matches are scheduled to be held on April 1, 2 and 3 at the National Stadium.This time, however, the traffic deputy inspector general (DIG) has made some changes in order to facilitate Karachiities. The routes leading towards the National Stadium will remain closed from 2pm instead of the 11am timing observed during the PSL final. As a concession, University Road is likely to remain open for commuters even during the match.According to the traffic plan for the T-20 Pakistan-West Indies series, the roads from Karsaz to National Stadium will be blocked for traffic. Vehicles will be  grey dunks diverted towards Drigh Road and then towards Rashid Minhas Road from there. Roads leading from Dalmi adidas classic a to the National Stadium will also be cl jordan bleu osed along with the road leading from NIPA to Quaid s Ujnh Transparency demanded in use of flood relief funds
 ISLAMABAD:Interim Interior Minister Sarfraz Bugti has said that the cases against Pakistan Muslim League-Nawaz Quaid Nawaz Sharif were baseless, contesting his disqualification in the Panama Papers case. Bugti, in an interview with a local Urdu newspaper, said no preferential treatment was adiletten original  being accorded to the PML-N as a level-playing field was being provided to all political parties.Nawaz, who was in self-imposed exile for the last four years, returned to the country on Oct 23 ahead of the general elections scheduled for Feb 8, 2024. The Islamabad High Cour nike air max95 t gave Nawaz bail in two corruption cases and prosecutors did not object, trusting he would turn up for the trial.Read: Imran summoned in court on Nov 27 in   pound 190 million settlement caseDuring the interview, the interim minister said that Pakistan Tehreek-e-Insaf Chairman Imran Khan was the   quot darling of the court  quot  and had been granted extraordinary privileges during his time in jail. Bugti  4er jordan emphasised that the faciliti

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  KARACHI:The Sindh High Court (SHC) issued on Tuesday n dunks women otices to Sindh chief secretary, the health department, medical superintendent  air max tw (MS) of Dr Ruth Pfau Civil Hospital, Karachi (CHK) and the provincial drug inspector on a plea pertaining to the supply of substandard  airforce life-saving drugs at CHK.A two-member bench, comprising Justice Muhammad Ali Mazhar and Justice Yousuf Ali Sayeed, issued the notices, in addition to summoning the health department secretary.The petitioner claimed that CHK had ordered 95,000 bottles of Cefixime, a life-saving drug, from a pharmaceutical company, Baxter. The company, however, supplied substandard medicines, which soon hardened into  cakes from powder,  and couldn't be used, he said, also informing the court that CHK MS and an inspector from the Drug Regulatory Authority had written letters to the pharmaceutical company complaining about the substandard drugs. But the issue was swept under the carpet after Baxter made an attractive offer, he added.He mainta Qjio SBP injects huge amount into banking system
 ISLAMABAD/LAHORE/QUETTA: The police crackdown against the Pakistan Tehreek-e-Insaf (PTI) leaders showed no sign of let-up on Friday, as senior PTI leaders Dr Shireen Mazari and Dr Yasmin Rashid, as well as Baloch adidas spezial vert istan Minister Mubeen Khilji, were arrested by police in raids carried out in Islamabad, Lahore, and Quetta.According to officials, the Islamabad police raided Shireen Mazari   39 s house during the wee hours of Friday. Her arrest came after a series of arrests of several other PTI leaders, including Imran nikeair  Khan, Asad Umar, Fawad Chaudhry, Shah Mahmood Qureshi, Omer Cheema, Ali Mohammad Khan, Senator Ejaz Chaudhry and others.All of these leaders other than Imran were arrested under Section 3 of the Maintenance of Pub adidas samba original schwarz lic Order (MPO).According to a statement issued by the Pakistan Tehreek-e-Insaf, former Punjab health minister Dr Yasmin Rashid has also been arrested.Our SVP Dr Shireen Mazari is being abducted in this precise moment. Police has also entered with guns her home, reach

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Fdwz Pirlo wins first trophy as Juventus beat Napoli in Italian Super Cup
   nike jordan Where the Fauji Fertilizer Company (FFC) is fulfilling its duty of providing farmers with quality manure, it is also creating awareness about the use of latest agricultural technology in obtaining better output from crops, the deputy manager says. Farmers can avail benefits from FFC s services and increase the output of their crops,  said Muhammad Zahid Aziz while addressing a seminar on profitable harvest of apple trees in Sibi on Sunday. The seminar was organised by FFC and attended by farmers and Pishin Agriculture Department officials.USDA s three-day agriculture workshop kicks offAziz said,  Before using the manure, it is necessary to undertake a survey of the land to determine if there is lack of essential minerals and if so how to fulfil the deficiency. FFC is providing farmers of the country free analysis on the usage of land and water. He said,  O air jordan2 ur agriculture experts bring samples of mud to FFC s latest computerised laboratory for analysis and then provide the campus 80 adidas  report to farm Mqou Pique probed over Saudi deal to host Spanish Super Cup
 MANCHESTER:Manchester City's Kevin De Bruyne has been ruled out of Wednesday's Manchester derby at Old Trafford by manager Pep Guardiola.The Belgium midfielder suffered the latest of several injuries this season when he was forced off in the champions' Premier League win at home to Tottenham on Saturday. It is nike air max mens  a muscular probl air max 720 em,  Guardiola told reporters on Tuesday.  We will see in the next days but tomorrow he is not available. Man City can move one point clear of title rivals Liverpool at t adidas campus red he top of the table heading into their final three games of the season with victory over United.