The doctor can tell you whether the hemophilia is mild, moderate or severe based on the levels of these clotting factors.
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Activated mast cells and basophils undergo a process called degranulation, during which they release histamine and other inflammatory chemical mediators cytokines, interleukins, leukotrienes, and prostaglandins from their granules into the surrounding tissue causing several systemic effects, such as vasodilation, mucous secretion, nerve stimulation, and smooth muscle contraction.