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Age over 35 Use of drugs such as cocaine, consumption of alcohol, or consumption of a lot of caffeine Abnormalities in the uterus, such as fibroids or scars, as may be caused by surgery, dilation and curettage D and C , radiation therapy, or infections A previous ectopic pregnancy the most important risk factor Previous abdominal surgery, especially surgery to sterilize the woman tubal ligation A previous infection with a sexually transmitted disease or pelvic inflammatory disease A history of infertility, use of fertility drugs, or use of assisted reproductive techniques If a pregnant woman has sudden, very severe pain in the lower abdomen or pelvis, doctors must quickly try to determine whether prompt surgery is required—as is the case when the cause is an ectopic pregnancy or appendicitis.