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  Chemical chaperones correct the misfolding of the mutant proteinResearchers have found that the conformational defect in a specific protein causes Autosomal Dominant Lateral Temporal Lobe Epilepsy (ADLT nike dunk panda E) which is a form of familial epilepsy. They showed that treatment with chemical corrector called "chemical chaperone" ameliorates increased seizure susceptibility in a mouse model of human epilepsy by correcting the conformational defect. This work has been published online December 8 in Nature Medicine.Mutations in the gene LGI1, encoding a secreted protein, cause familial temporal lobe epilepsy. The research group of Professor Masaki Fukata, Associate Professor Yuko Fukata, and Assistant Professor Norihiko Yokoi of the National Institute for Physiological Sciences (NIPS), N adidas yeezys ational Institutes of Natural Sciences (NINS), in collaboration with the group of Professor Masahiko Watanabe of the Hokkaido University Graduate School of Medicine,  yeezy foam Professor Dies Meijer of the Erasmus U  ISLAMABAD:The government has planned to relax rules governing public procurement and the bidding process in a bid to award multibillion-rupee contracts without facing obstacles, say officials.Earlier, the government has drawn flak for violating publi newbalance 550 c procurement rules in the award of lucrative contracts. For instance, a liquefied natural gas (LNG) terminal-building contract given to the Engro group by the Economic Coordination Committee (ECC) sparked scathing criticism of the government, which was forced to float a tender.Pakistan awards $2 billion LNG pipeline contract to sanction-hit Russian firmThe cabinet, in its meeting held on November 23, considered a proposal for amending the public procurement rules of 2004. It reviewed a summary submitted by the Cabinet Division for amendments and constituted a committee to new balance 991  make changes to the Public Procurement Regulatory Authority (PPRA) Ordinance 2002 and PPRA Rules 2004.The committee will be headed by Water and Powe newbalance 9060 r Minister Khawaja Muh

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