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KARACHI:The Sindh government barely spent 46% of the development funds in the fiscal year 2015-2016, pointed out Muttahida Qaumi Movement (MQM) MPA Mehmood Razzaq during the Sindh Assembly session on Tuesday.Opposition lawmakers, while taking part in the budget discussion, criticised the government for not utilising the development funds. They suggested that the government devise a social security plan and utilise the funds at proper time.鈥淵ou have allocated a Rs569-billion budget with  ugg ultra mini Rs225 billion for development programmes,鈥?said Razzaq. 鈥淗ow can yo ugg boots damen u make s nb ure that the money is spent as the government has hardly spent 46% funds in this current year?鈥?He said that there is zero per cent utilisation of funds in many departments, which shows the incompetency on part of the incumbent government.Misplaced priorities : Less than 1% of Sindh budget allocated for environmentSaeed Nizamani of the Pakistan Muslim League - Functional (PML-F) said that the government has earmarked around Rs160  New computational strategies reported this week in Science might help realize the promise of peptide-based d yeezy rugs. Peptides are similar to protein molecules, but differ in their smaller size, structure and functions.Macrocyclic peptides have sparked pharmaceutical industry interest, because they have certain physical and chem chanclas yeezy ical properties that could become the basis of a new generation of medications.Small peptides have the benefits of small molecule drugs, like aspi dunk rin, and large antibody therapies, like rituximab, with fewer drawbacks. They are stable like small molecules and potent and selective like antibodies.An example of a macrocyclic peptide drug success story is cyclosporine, an immunosuppressant for organ transplants and some autoimmune disorders.Before the work described in the Science paper, there was no way to systematically design ordered peptide macrocycles like cyclosporine.Naturally occurring peptides that might serve as reliable starting points, or scaffolds, are few