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NOXXON Pharma AG has announced successful completion of the first phase I trial with its anti-inflammatory Spiegelmer庐 NOX-E36. This drug candidate will be developed for the treatment of complications of type 2 diabetes, preferentially diabetic nephropathy, but al
asics gel so others.The phase I study, conducted in the United Kingdom, was performed to evaluate the safety, tolerability, pharmacokinetics a
jordan low nd pharmacodynamics of the chemokine inhibitor NOX-E36 in 72 healthy volunteers. A double-blind, placebo-controlled, single ascending dose study design was used to investigate escalating intravenous doses, the bioavailability of subcutaneous doses and potential gender differences.Preliminary results show NOX-E36 to be safe and well tolerated at all dose levels in both the intravenous and subcutaneous groups. NOX-E36 showed dose-linear pharmacokinetics, leading to plasma concentrations well above t
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