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  Halozyme Therapeutics, Inc.has announced thatRoche has dosed the first patient in a Phase 1 pharmacokinetic clinical trial with a subcutaneous formulation using Enhanze Technology of a biologic directed to a Roche exclusive target. This has triggered a milestone pa dunk sb yment under the agreement.Roche has also selected an additional exclusive target under the existing license and collaboration agreement. Under the terms of the agreement, Roche will pay Halozyme for exclusive, global rights for the application of its hyaluronidase enzyme nike dunks , rHuPH20, to a fourth biologic target selected by Roche.Roche has also maintained its rights to other targets covered in the license and collaboration agreement. An aggregate payment of $10.25 millio dunk low n will be made to Halozyme for commencing a Phase 1 clinical trial, exercising exclusive global rights to a fourth biologic target and for annual maintenance fees.Halozyme also announced that it has entered into a supply agreement with Roche to provide rHuPH20 for  England duo Alex Hales and Stuart Broad took to Twitter to express their frustration over a controversial catch in their fourth Test?€?s day one against Pakistan..Opening batsman Hales was furious when he was given out to a low catch off Mohammad Amir?€?s delivery early on in England?€?s first innings. Yasir Shah had claimed a diving catch and didn?€?t hesitate to celebrate, but the batsman stood his ground. He walked off the field only after third umpire  adidas samba damen Joel Wilson confirmed standing umpire Bruce Oxenford?€?s initial decision.Another adidas campus  look at Hales' departure, real time and slo-mo stanley website . Thoughts? Tough one for the opener in last Test of summer ???? https://t.co/1okdpi6SP1— England Cricket (@englandcricket) August 11, 2016Good teams do not make mistakes like dropping catches: Mushtaq AhmedHowever, Broad vented his displeasure on Twitter in a reply English newspaper The Daily Mirror?€?s cricket correspondent?€?s tweet.replays are unclear? You don't believe that do you?— Stuart Broad (@St