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  Researchers at the University of Toronto have discovered how a brief disruption to a molecular pathway in the guts of mice before they are born can compromise adult immunity to a common and often deadly intestinal virus.The researchers found that in utero inhibition of molecular signaling in the 鈥榣ymphotoxin pathway,鈥?long known as important in the development of the immune system, prevented a robust antibody response in adult mice to rotavirus 鈥?which in humans causes an estimated 215,000 deaths annually, mostly in the developing world.That early disruption limits the ability of the immune system to later trigger and generate production of Immunoglobulin A (IgA) antibod dunk nike ies, the researchers showed. It also interferes with the nature and function of cells in the gut that support the antibody response, called mesenteric lymph node stromal cells.鈥淚t was surprising that these non-immune stromal cells were so important to the jordan  immune response,鈥?says Jennifer G dunk high nike ommerman, a professor of Immunol  LONDON:Novak Djokovic brushed past France鈥檚 Adrian Mannarino 6-4, 6-3, 7-6(5) yesterday to book his place in the third round of Wimbledon.The defending champion, aiming for his third consecutive title, played well within himself and was rarely troubled during the second-round match.Mannarino, ranked 55, put up spirited resistance in the third set to force a tiebreak but was ultimately swept off Centre Court by the Serbian鈥檚 laser-guided groundstrokes.聽 World number one Djokovic holds all four grand slam titles and has another historic mark in his sights.The 2 stanley website 9-year-old is aiming to become the first man since Rod Laver in 1969 to achieve the calendar Grand Slam 鈥?winning the four majors in a single season.Federer ends Willis's Wimbledon fa boots kaufen irytaleCoachless Berdych battles to four-set winTomas Berdych battled the elements and a gritty display by unseeded Croatian Ivan Dodig at a rain-ravaged Wimbledon yesterday, sealing a four-set victory h stanleycup e admitted should have been his the previous day.